Article
Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees.
Biological psychiatry - 1 Jul 2004
Schulze Thomas G, Buervenich Silvia, Badner Judith A, Steele C J M, Detera-Wadleigh Sevilla D, Dick Danielle, Foroud Tatiana, Cox Nancy J, MacKinnon Dean F, Potash James B, Berrettini Wade H, Byerley William, Coryell William, DePaulo J Raymond, Gershon Elliot S, Kelsoe John R, McInnis Melvin G, Murphy Dennis L, Reich Theodore, Scheftner William, Nurnberger John I, McMahon Francis J
Abstract excerpt
BACKGROUND: We have reported genetic linkage between bipolar disorder and markers on chromosome 6q16.3-22.1 in the National Institute of Mental Health Genetics Initiative wave 3 pedigrees. Here we test for: 1) robustness of the linkage to differing analysis methods, genotyping error, and gender-specific maps; 2) parent-of-origin effects; and 3) interaction with markers within the schizophrenia linkage region on...
Topics
- Bipolar Disorder
- Chromosomes, Human, Pair 6
- Epistasis, Genetic
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Lod Score