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Article

Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHC

12 Mar 2012

Abstract excerpt

BACKGROUND: The Tasmanian devil (Sarcophilus harrisii) is currently under threat of extinction due to an unusual fatal contagious cancer called Devil Facial Tumour Disease (DFTD). DFTD is caused by a clonal tumour cell line that is transmitted between unrelated individuals as an allograft without triggering immune rejection due to low levels of Major Histocompatibility Complex (MHC) diversity in Tasmanian devils....

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PMID: 22404855
DOI: 10.1186/1471-2164-13-87

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