Article
p53 mutations and c-erbB-2 amplification in intraductal and invasive breast carcinomas of high histologic grade.
Japanese journal of cancer research : Gann - 1 Apr 1993
Tsuda H, Iwaya K, Fukutomi T, Hirohashi S
Abstract excerpt
In order to clarify the clinical significance of mutations of the p53 gene and amplification of the c-erbB-2 gene in breast carcinoma, these gene alterations were examined in 101 invasive, seven predominantly intraductal and 10 intraductal breast carcinomas by single-strand conformation polymorph...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Breast Neoplasms
- Carcinoma, Intraductal, Noninfiltrating
- Female
- Gene Amplification
- Genes, p53
- Humans
- Middle Aged
- Molecular Sequence Data
- Mutation
- Neoplasm Invasiveness
- Proto-Oncogene Proteins
- Receptor, ErbB-2