Article
p53 mutations and c-erbB-2 amplification in intraductal and invasive breast carcinomas of high histologic grade.
Japanese journal of cancer research : Gann - 1 Apr 1993
Tsuda H, Iwaya K, Fukutomi T, Hirohashi S
Abstract excerpt
In order to clarify the clinical significance of mutations of the p53 gene and amplification of the c-erbB-2 gene in breast carcinoma, these gene alterations were examined in 101 invasive, seven predominantly intraductal and 10 intraductal breast carcinomas by single-strand conformation polymorphism-direct sequencing or Southern blot-hybridization analysis. p53 mutations were detected in 32 (32%) of the invasive...
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