Article
Detection of pancreatic carcinoma: diagnostic value of K-ras mutations in circulating DNA from serum.
Digestive diseases and sciences - 1 Oct 1999
Theodor L, Melzer E, Sologov M, Idelman G, Friedman E, Bar-Meir S
Abstract excerpt
Somatic activating mutations at codon 12 of the K-ras gene are present in the majority of exocrine pancreatic cancers and occur early in tumorgenesis. The aim of this study was to test the feasibility of using a mutated K-ras gene from the serum as a potential tumor marker for detection of exocrine pancreatic carcinoma. Codon 12 K-ras mutations were examined in DNA extracted from the sera of 20 patients with...
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