Article
K-ras mutations in duodenal aspirate without secretin stimulation for screening of pancreatic and biliary tract carcinoma.
Cancer - 15 Oct 1999
Watanabe H, Ha A, Hu Y X, Ohtsubo K, Yamaguchi Y, Motoo Y, Okai T, Toya D, Tanaka N, Sawabu N
Abstract excerpt
BACKGROUND: K-ras mutations at codon 12 (KRM) have been detected in over 80% of tissues and pure pancreatic juice (PPJ) samples from patients with pancreatic carcinoma (PCa) and are promising genetic tumor markers. Aspirating PPJ not only requires technical skill, but is also exhausting for patients. The authors attempted to evaluate whether the detection of KRM in the duodenal aspirate (DA) obtained immediately...
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