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Article

Loss of heterozygosity (LOH), malignancy grade and clonality in microdissected prostate cancer.

British journal of cancer - 1 Feb 1999

Hügel A, Wernert N

Abstract excerpt

The aim of the present study was to find out whether increasing malignancy of prostate carcinoma correlates with an overall increase of loss of heterozygosity (LOH), and whether LOH typing of microdissected tumour areas can help to distinguish between multifocal or clonal tumour development. In 47 carcinomas analysed at 25 chromosomal loci, the overall LOH rate was found to be significantly lower in grade 1 areas...

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Identifiers

PMID: 10027329
DOI: 10.1038/sj.bjc.6690087
PMCID: PMC2362403

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