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Article

PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2013

Yoshimoto Maisa, Ding Keyue, Sweet Joan M, Ludkovski Olga, Trottier Greg, Song Kyu S, Joshua Anthony M, Fleshner Neil E, Squire Jeremy A, Evans Andrew J

Abstract excerpt

Prostatic adenocarcinoma is an epithelial malignancy characterized by marked histological heterogeneity. It most often has a multifocal distribution within the gland, and different Gleason grades may be present within different foci. Data from our group and others have shown that the genomic deletion of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor gene and the disruption of...

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Source

Identifiers

PMID: 23018874
DOI: 10.1038/modpathol.2012.162

Genes

PTEN
ERG
TMPRSS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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