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Article

A novel splice variant ofHER2 with increased transformation activity

1 Oct 1998

Abstract excerpt

The HER2 proto-oncogene (also known as neu or c-erbB-2) belongs to the epidermal growth factor receptor family. HER2 is frequently amplified in human carcinomas. Gene amplification or overexpression of HER2 has been correlated with poor prognosis in several human cancers. Point mutation in the rat HER2 homolog, neu, is involved in the formation of rat neuroblastomas. However, no similar mutation in HER2 has been...

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Identifiers

PMID: 9808159
DOI: 10.1002/(sici)1098-2744(199810)23:2<62::aid-mc2>3.0.co;2-o

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