Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes.

Carcinogenesis - 1 Mar 2009

Sasaki Rumi, Narisawa-Saito Mako, Yugawa Takashi, Fujita Masatoshi, Tashiro Hironori, Katabuchi Hidetaka, Kiyono Tohru

Abstract excerpt

Ovarian surface epithelium (OSE) is considered to give rise to epithelial ovarian carcinomas (EOCs). To elucidate early processes contributing to the development of EOCs from the OSE, two batches of primary human OSE cells were transduced with non-viral human genes (mutant Cdk4, cyclinD1 and hTERT) so as to efficiently establish normal diploid OSE cells without chromosomal instability. Then defined genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Instability
Share to Cyclin D1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase 4

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

Share to Telomerase

Share to Transduction, Genetic

Source

Identifiers

PMID: 19126650
DOI: 10.1093/carcin/bgp007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes.PMID 19126650Read ↗

Modelling genetic and clinical heterogeneity in epithelial ovarian cancersSemantic proximity Read ↗

Epithelial ovarian cancer: Focus on genetics and animal modelsSemantic proximity Read ↗

Cellular models of development of ovarian high‐grade serous carcinoma: A review of cell of origin and mechanisms of carcinogenesisSemantic proximity Read ↗

Modeling high-grade serous ovarian carcinogenesis from the fallopian tubeSemantic proximity Read ↗

Establishment of five immortalized human ovarian surface epithelial cell lines via SV40 T antigen or HPV E6/E7 expressionSemantic proximity Read ↗

Both Fallopian Tube and Ovarian Surface Epithelium Can Act as Cell-of-Origin for High Grade Serous Ovarian CarcinomaSemantic proximity Read ↗

Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma.Semantic proximity Read ↗

Molecular Requirements for Transformation of Fallopian Tube Epithelial Cells into Serous CarcinomaSemantic proximity Read ↗

Development of Low-Grade Serous Ovarian Carcinoma from Benign Ovarian Serous Cystadenoma CellsSemantic proximity Read ↗

Characterization of three new serous epithelial ovarian cancer cell lines.Semantic proximity Read ↗

Tumorigenesis and peritoneal colonization from fallopian tube epitheliumSemantic proximity Read ↗

Most commonly mutated genes in High Grade Serous Ovarian Carcinoma are nonessential for ovarian surface epithelial stem cell transformationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.