Article
In vivo survivors of transformed mouse ovarian surface epithelial cells display diverse phenotypes for gene expression and tumorigenicity.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2008
Li Xiao-Lin, Zhang Dong-Qing, Wang David, Knight David S, Yin Lija, Bao Jianxiong, Liu Yong-Yu, Glass Jonathan, Mathis J Michael, Zhang Qian-Jin
Abstract excerpt
Ovarian cancer is the fifth most common cause of cancer death in women. Due to a lack of appropriate animal models, studies involving tumorigenicity, tumor progression and immune response at the molecular level are limited. We isolated many clones derived from thesurvivors of a transformed mouse ovarian epithelial cell line IG-10 in immune- competent mice and found that the clones displayed diverse phenotypes....
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