Article
In vivo survivors of transformed mouse ovarian surface epithelial cells display diverse phenotypes for gene expression and tumorigenicity.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2008
Li Xiao-Lin, Zhang Dong-Qing, Wang David, Knight David S, Yin Lija, Bao Jianxiong, Liu Yong-Yu, Glass Jonathan, Mathis J Michael, Zhang Qian-Jin
Abstract excerpt
Ovarian cancer is the fifth most common cause of cancer death in women. Due to a lack of appropriate animal models, studies involving tumorigenicity, tumor progression and immune response at the molecular level are limited. We isolated many clones derived from thesurvivors of a transformed mouse ovarian epithelial cell line IG-10 in immune- competent mice and found that the clones displayed diverse phenotypes....
Topics
- Animals
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Disease Models, Animal
- Epithelial Cells
- Female
- Gene Expression Regulation, Neoplastic
- Genes, MHC Class I
- Humans
- Mice
- Mice, Inbred C57BL
- Ovarian Neoplasms