Article
Effects of intra-locus recombination of HLA polymorphism.
Hereditas - 1 Jan 1997
Satta Y
Abstract excerpt
The observed number of alleles (n(a)) at some human major histocompatibility complex (HLA) loci is more than twice as large as the pairwise mean number (KB) of nonsynonymous nucleotide substitutions in the peptide-binding region (PBR), although the KB is about the same as that predicted by a model of balancing selection. In order to assess the joint effect of intra-locus recombination and balancing selection on...
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