Selection, convergence, and intragenic recombination in HLA diversity.

Article

Selection, convergence, and intragenic recombination in HLA diversity.

Genetica - 1 Jan 1998

Takahata N, Satta Y

Abstract excerpt

To account for high degrees of human leukocyte antigen (HLA) diversity, a method is proposed for detecting intragenic recombination or gene conversion separately from parallel substitutions or convergent evolution. An application of the method to HLA protein sequences suggests that intragenic rec...

Topics

Amino Acid Sequence
Computer Simulation
Evolution, Molecular
Gene Conversion
Genetic Variation
HLA Antigens
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
Humans
Models, Genetic
Models, Statistical
Recombination, Genetic
Selection, Genetic

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