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Article

Autoinhibitory mechanisms in receptor tyrosine kinases.

Frontiers in bioscience : a journal and virtual library - 1 Feb 2002

Hubbard Stevan R

Abstract excerpt

Receptor tyrosine kinases (RTKs) are single-pass transmembrane receptors that possess intrinsic tyrosine kinase catalytic activity in their cytoplasmic domains. RTKs are critical components in signal transduction pathways involved in cellular proliferation, differentiation, migration, and metabolism. This large protein family includes the receptors for many growth factors and for insulin. Ligand binding to the...

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PMID: 11815286
DOI: 10.2741/A778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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