Article
Genotype analysis of prepro-vasopressin signal peptide in vasopressin-producing and -non-producing lung tumors.
Life sciences - 1 Jan 1997
Shoji M, Kimura T, Ota K, Yamaji T, Ishibashi M, Ohta M, Sasano H, Kawarabayashi Y, Kimura N, Funyu T, Mori T, Sahata T
Abstract excerpt
A polymorphism in the nucleic acid sequence encoding the signal peptide of the human prepro-vasopressin (AVP) has been reported in an AVP producing small cell lung carcinoma (SCLC) cell line. The difference predicts expression in tumor cells of a variant signal peptide with Pro for Leu 11. To clarify whether this difference is required for AVP secretion from SCLC cells and/or reflects increased mutagenesis in...
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