Article
Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma.
Peptides - 1 Jan 1997
North W G, Fay M J, Longo K, Du J
Abstract excerpt
Vasopressin and other neuropeptides are believed to serve as autocrine growth factors for small-cell carcinoma of the lung (SCCL), and these mitogenic influences are reported to involve increases in intracellular Ca2+. Of the classical and variant forms of SCCL, the latter is not only more drug-resistant but also refractory to vasopressin, and other peptides, with respect to changes in intracellular Ca2+. It is...
Topics
- Amino Acid Sequence
- Base Sequence
- Calcium
- Carcinoma, Small Cell
- Cloning, Molecular
- DNA Primers
- Genetic Variation
- Humans
- Inositol Phosphates
- Lung Neoplasms
- Polymerase Chain Reaction