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Article

Loss of heterozygosity for genes on 11p and the clinical course of patients with lung carcinoma.

Cancer research - 15 Apr 1990

Skinner M A, Vollmer R, Huper G, Abbott P, Iglehart J D

Abstract excerpt

Forty-five primary human lung carcinomas were evaluated for the loss of heterozygosity for genes on the short end of chromosome 11. Of 40 evaluable heterozygous cases, loss of the 11p genes c-H-ras and insulin was documented in nine cases (22%). The clinical parameters investigated for each patient included the disease stage at presentation, the presence of metastatic disease in either bronchial or mediastinal...

Topics

Alleles
Carcinoma, Bronchogenic
Chromosome Deletion
Chromosomes, Human, Pair 11
Follow-Up Studies
Genes, ras
Heterozygote
Humans
Insulin
Lung Neoplasms
Neoplasm Staging

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Identifiers

PMID: 2180565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2180565-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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