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Article

An ACTH-producing small cell lung cancer expresses aberrant glucocorticoid receptor transcripts from a normal gene.

Molecular and cellular endocrinology - 25 Jul 1998

Parks L L, Turney M K, Detera-Wadleigh S, Kovacs W J

Abstract excerpt

ACTH production by non-pituitary tumors is generally not suppressible by exogenous glucocorticoid administration. We had postulated that defects in the glucocorticoid receptor (GR) signaling system might be responsible for this apparent glucocorticoid resistance and had previously demonstrated that DMS-79 cells, derived from an ectopic ACTH-producing tumor, express an abnormal GR mRNA. In this DMS-79 cell GR the...

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PMID: 9783913
DOI: 10.1016/s0303-7207(98)00107-5

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