Article
An ACTH-producing small cell lung cancer expresses aberrant glucocorticoid receptor transcripts from a normal gene.
Molecular and cellular endocrinology - 25 Jul 1998
Parks L L, Turney M K, Detera-Wadleigh S, Kovacs W J
Abstract excerpt
ACTH production by non-pituitary tumors is generally not suppressible by exogenous glucocorticoid administration. We had postulated that defects in the glucocorticoid receptor (GR) signaling system might be responsible for this apparent glucocorticoid resistance and had previously demonstrated th...
Topics
- Adrenocorticotropic Hormone
- Base Sequence
- Binding Sites
- Blotting, Southern
- Carcinoma, Small Cell
- DNA
- Humans
- Introns
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- RNA Precursors
- RNA Splicing
- RNA, Messenger
- Receptors, Glucocorticoid
- Tumor Cells, Cultured