Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa.

doi:10.1016/s0046-8177(97)90230-6

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Article

Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa.

Human pathology - 1 Dec 1997

Nucci M R, Robinson C R, Longo P, Campbell P, Hamilton S R

Abstract excerpt

Aberrant crypt foci (ACF) in colorectal mucosa are proposed to be the earliest morphological lesion in the development of neoplasia, but their characteristics remain controversial. We therefore studied the epithelial phenotype and genotype of ACF from patients with familial adenomatous polyposis...

Topics

Adult
Aged
CA-19-9 Antigen
Colonic Polyps
Colorectal Neoplasms
Gangliosides
Genes, ras
Genotype
Humans
Intestinal Mucosa
Lectins
Middle Aged
Mutation
Peanut Agglutinin
Phenotype
Plant Lectins
Proliferating Cell Nuclear Antigen
Proto-Oncogene Mas

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