Article
Morphologic and molecular characterization of traditional serrated adenomas of the distal colon and rectum.
The American journal of surgical pathology - 1 Sept 2014
Wiland Homer O, Shadrach Bonnie, Allende Daniela, Carver Paula, Goldblum John R, Liu Xiuli, Patil Deepa T, Rybicki Lisa A, Pai Rish K
Abstract excerpt
Of the serrated polyps, the origin, morphologic features, molecular alterations, and natural history of traditional serrated adenomas (TSAs) are the least understood. Recent studies suggest that these polyps may arise from precursor lesions. The frequencies of KRAS and BRAF mutations vary between these studies, and only 1 small study has measured CpG island methylation using current markers of methylation....
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