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Article

Mutations synthetically lethal with tpm1delta lie in genes involved in morphogenesis.

Genetics - 1 Dec 1997

Wang T, Bretscher A

Abstract excerpt

Yeast contains two genes, TPM1 and TPM2, encoding tropomyosins, either of which can provide an essential function in the yeast cytoskeleton. To elucidate more clearly the function of the major tropomyosin, encoded by TPM1, we have isolated mutations that confer synthetic lethality with the null mutant of TPM1. Here we describe a phenotypic and genetic analysis of mutations in TSL1/BEM2, TSL2, TSL3, TSL5, and TSL6...

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Source

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Identifiers

PMID: 9409824
DOI: 10.1093/genetics/147.4.1595
PMCID: PMC1208334

Genes

TPM1
TPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mutations synthetically lethal with tpm1delta lie in genes involved in morphogenesis.PMID 9409824Read ↗

Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.Semantic proximity Read ↗

Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport.Semantic proximity Read ↗

Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.Semantic proximity Read ↗

Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae.Semantic proximity Read ↗

Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton.Semantic proximity Read ↗

Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions.Semantic proximity Read ↗

The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast.Semantic proximity Read ↗

Synthetic interactions of the post-Golgi sec mutations of Saccharomyces cerevisiae.Semantic proximity Read ↗

Ras regulates the polarity of the yeast actin cytoskeleton through the stress response pathway.Semantic proximity Read ↗

Composite synthetic lethal identification of membrane traffic inhibitors.Semantic proximity Read ↗

The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton.Semantic proximity Read ↗

The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.Semantic proximity Read ↗

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