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Article

Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.

The EMBO journal - 1 Oct 2004

Audhya Anjon, Loewith Robbie, Parsons Ainslie B, Gao Lu, Tabuchi Mitsuaki, Zhou Huilin, Boone Charles, Hall Michael N, Emr Scott D

Abstract excerpt

To further understand the roles played by the essential phosphoinositide PI4,5P(2), we have used a synthetic lethal analysis, which systematically combined the mss4(ts) mutation, partially defective in PI4P 5-kinase activity, with each of approximately 4700 deletion mutations. This genomic screening technique uncovered numerous new candidate effectors and regulators of PI4,5P(2) in yeast. In particular, we...

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Identifiers

PMID: 15372071
DOI: 10.1038/sj.emboj.7600384
PMCID: PMC522789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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