Article
Effect of phenotype on the transcription of the genes for platelet-derived growth factor (PDGF) isoforms in human smooth muscle cells, monocyte-derived macrophages, and endothelial cells in vitro.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1997
Krettek A, Fager G, Lindmark H, Simonson C, Lustig F
Abstract excerpt
Proliferation of arterial smooth muscle cells (ASMCs) contributes considerably to enlargement of the arterial wall during atherosclerosis. The platelet-derived growth factor (PDGF) is a well-known mitogen and chemoattractant for ASMCs. Quantitative reverse transcription-polymerase chain reaction showed that cells appearing in atherosclerotic lesions, such as ASMCs, endothelial cells, and monocytes/macrophages,...
Topics
- Adult
- Becaplermin
- Cell Differentiation
- Chemotaxis
- Endothelium, Vascular
- Female
- Gene Expression Regulation
- Humans
- Leukocytes, Mononuclear
- Macrophages
- Molecular Weight
- Muscle, Smooth, Vascular
- Phenotype