Article
PAF-receptor is preferentially expressed in a distinct synthetic phenotype of smooth muscle cells cloned from human internal thoracic artery: functional implications in cell migration.
Biochemical and biophysical research communications - 4 Aug 2006
Stengel Dominique, O'Neil Caroline, Brochériou Isabelle, Karabina Sonia-Athina, Durand Hervé, Caplice Noel M, Pickering J Geoffrey, Ninio Ewa
Abstract excerpt
Platelet-activating-Factor (PAF) and its structural analogues formed upon low density lipoprotein oxidation are involved in atherosclerotic plaque formation and may signal through PAF-receptor (PAF-R) expressed in human macrophages and in certain smooth muscle cells (SMCs) in the media, but rarely in the intima of human plaques. Our aim was to determine which SMC phenotype expresses PAF-R and whether this...
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