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Article

Human macrophages modulate the phenotype of cultured rabbit aortic smooth muscle cells through secretion of platelet-derived growth factor.

European journal of clinical investigation - 1 Jul 1992

Morisaki N, Koyama N, Kawano M, Mori S, Umemiya K, Koshikawa T, Saito Y, Yoshida S

Abstract excerpt

Phenotypic change of aortic smooth muscle cells (SMC) is a key step for their abnormal proliferation in atheromatous lesions. In this study modulation of the growth properties of SMC by macrophages was investigated to clarify the mechanism regulating the SMC phenotype. Cultured rabbit SMC preincubated with either macrophages derived from human peripheral monocytes, or conditioned medium from macrophages grew...

Topics

Animals
Cell Division
Cells, Cultured
Culture Media
Humans
Interleukin-1
Macrophages
Mitogens
Muscle, Smooth, Vascular
Phenotype
Platelet-Derived Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1516593
DOI: 10.1111/j.1365-2362.1992.tb01491.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1516593-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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