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Article

A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease.

The Journal of clinical investigation - 1 Apr 1997

Wittrup H H, Tybjaerg-Hansen A, Abildgaard S, Steffensen R, Schnohr P, Nordestgaard B G

Abstract excerpt

Lipoprotein lipase degrades triglycerides in plasma and as a byproduct produces HDL particles. Genetic variation in lipoprotein lipase may therefore affect cardiovascular risk. We tested 9,214 men and women from a general population sample and 948 patients with ischemic heart disease for the Asn291Ser substitution in lipoprotein lipase. The allele frequency in the general population was 0.024 and 0.026 for women...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9120004
DOI: 10.1172/JCI119323
PMCID: PMC507980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease.PMID 9120004Read ↗

[Frequent mutation doubles the risk of ischemic heart disease in women].Semantic proximity Read ↗

A common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascular disease in patients with familial hypercholesterolemia.Semantic proximity Read ↗

A common mutation in lipoprotein lipase confers a 2-fold increase in risk of ischemic cerebrovascular disease in women but not in men.Semantic proximity Read ↗

Lipoprotein lipase genetic variation and gender-specific ischemic cerebrovascular disease risk.Semantic proximity Read ↗

A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis.Semantic proximity Read ↗

Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease. A meta-analysis.Semantic proximity Read ↗

Functional variants in the lipoprotein lipase gene and risk cardiovascular disease.Semantic proximity Read ↗

Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans.Semantic proximity Read ↗

Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: studies in the fasting and postprandial states: the European Atherosclerosis Research Studies.Semantic proximity Read ↗

Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study.Semantic proximity Read ↗

Heterozygous lipoprotein lipase deficiency: frequency in the general population, effect on plasma lipid levels, and risk of ischemic heart disease.Semantic proximity Read ↗

Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis.Semantic proximity Read ↗

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