Article
The C-480T hepatic lipase polymorphism is associated with HDL-C but not with risk of coronary heart disease.
Clinical genetics - 1 Aug 2006
McCaskie P A, Cadby G, Hung J, McQuillan B M, Chapman C M L, Carter K W, Thompson P L, Palmer L J, Beilby J P
Abstract excerpt
High-density lipoprotein cholesterol (HDL-C) is a known predictor of coronary heart disease (CHD). Studies have shown that the C-480T polymorphism of the hepatic lipase (HL) gene is predictive of HDL-C; however, its observed relationship with the risk of CHD has been inconsistent. We analysed four biallelic polymorphisms in the HL gene in participants from three independent Western Australian populations. Samples...
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