Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state.

doi:10.1073/pnas.94.26.14273

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Article

Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state.

Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 1997

Kim J M, Altenbach C, Thurmond R L, Khorana H G, Hubbell W L

Abstract excerpt

The Glu-134-Arg-135 residues in rhodopsin, located near the cytoplasmic end of the C helix, are involved in G protein binding, or activation, or both. Furthermore, the charge-neutralizing mutation Glu-134 to Gln-134 produces hyperactivity in the activated state and produces constitutive activity...

Topics

Animals
Humans
Mutation
Photic Stimulation
Protein Conformation
Rhodopsin
Signal Transduction

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