Article
Constitutive activation of opsin: influence of charge at position 134 and size at position 296.
Biochemistry - 15 Jun 1993
Cohen G B, Yang T, Robinson P R, Oprian D D
Abstract excerpt
In previous studies, mutation of Lys296 or Glu113 in opsin has been shown to result in constitutive activation of the protein--that is, these mutants can activate the G protein transducin in the absence of chromophore and in the absence of light. These and other data have led to the suggestion that a salt bridge between Lys296 and Glu113 helps to constrain opsin to an inactive conformation. It is shown here that...
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