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Article

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin.

Science (New York, N.Y.) - 1 Nov 1996

Farrens D L, Altenbach C, Yang K, Hubbell W L, Khorana H G

Abstract excerpt

Conformational changes are thought to underlie the activation of heterotrimeric GTP-binding protein (G protein)-coupled receptors. Such changes in rhodopsin were explored by construction of double cysteine mutants, each containing one cysteine at the cytoplasmic end of helix C and one cysteine at...

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Identifiers

PMID: 8864113
DOI: 10.1126/science.274.5288.768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8864113-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin.PMID 8864113Read ↗

G-protein activation of the dark-state conformation of the visual G protein-coupled receptor rhodopsin by releasing critical structural constraints.Semantic proximity Read ↗

Mapping of the amino acids in the cytoplasmic loop connecting helices C and D in rhodopsin. Chemical reactivity in the dark state following single cysteine replacements.Semantic proximity Read ↗

A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin.Semantic proximity Read ↗

Intramolecular interactions that induce helical rearrangement upon rhodopsin activation: light-induced structural changes in metarhodopsin IIa probed by cysteine S-H stretching vibrations.Semantic proximity Read ↗

Highly conserved tyrosine stabilizes the active state of rhodopsin.Semantic proximity Read ↗

Dynamics of the Second Extracellular Loop Control Transducer Coupling of Peptide-Activated GPCRs.Semantic proximity Read ↗

Critical role of electrostatic interactions of amino acids at the cytoplasmic region of helices 3 and 6 in rhodopsin conformational properties and activation.Semantic proximity Read ↗

Rhodopsin determinants for transducin activation: a gain-of-function approach.Semantic proximity Read ↗

Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.Semantic proximity Read ↗

Cysteine Modification: Probing Channel Structure, Function and Conformational Change.Semantic proximity Read ↗

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation.Semantic proximity Read ↗

Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment.Semantic proximity Read ↗

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