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New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations.

Cellular and molecular life sciences : CMLS - 7 Jan 2022

Herrera-Hernández María Guadalupe, Razzaghi Neda, Fernandez-Gonzalez Pol, Bosch-Presegué Laia, Vila-Julià Guillem, Pérez Juan Jesús, Garriga Pere

Abstract excerpt

Mutations in the photoreceptor protein rhodopsin are known as one of the leading causes of retinal degeneration in humans. Two rhodopsin mutations, Y102H and I307N, obtained in chemically mutagenized mice, are currently the subject of increased interest as relevant models for studying the process of retinal degeneration in humans. Here, we report on the biochemical and functional characterization of the...

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Identifiers

PMID: 34997336
DOI: 10.1007/s00018-021-04086-0
PMCID: PMC8741697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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