Article
Hyperproduction of L-threonine by an Escherichia coli mutant with impaired L-threonine uptake.
Bioscience, biotechnology, and biochemistry - 1 Nov 1997
Okamoto K, Kino K, Ikeda M
Abstract excerpt
An efficient production strain for L-threonine fermentation was derived from Escherichia coli by multiple rounds of mutation programs that aimed at deregulation of the L-threonine biosynthetic pathway and blocking of L-threonine degradation pathways. When the optimum amount of DL-methionine was added, this strain KY10935, an L-methionine auxotroph, gave 100 g/liter L-threonine after 77 h cultivation. In this...
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