Article
A C-terminal deletion in Corynebacterium glutamicum homoserine dehydrogenase abolishes allosteric inhibition by L-threonine.
Gene - 30 Oct 1991
Archer J A, Solow-Cordero D E, Sinskey A J
Abstract excerpt
In Escherichia coli, Bacillus subtilis and Corynebacterium glutamicum, homoserine dehydrogenase (HD), the enzyme after the branch point of the threonine/methionine and lysine biosynthetic pathways, is allosterically inhibited by L-threonine. To investigate the regulation of the C. glutamicum HD enzyme by L-threonine, the structural gene, hom, was mutated by UV irradiation of whole cells to obtain a deregulated...
Topics
- Allosteric Regulation
- Amino Acid Sequence
- Base Sequence
- Chromosome Deletion
- Cloning, Molecular
- Corynebacterium
- Gene Expression Regulation, Bacterial
- Homoserine Dehydrogenase
- Molecular Sequence Data
- Mutagenesis