Article
Superpositioning of deletions promotes growth of Escherichia coli with a reduced genome.
DNA research : an international journal for rapid publication of reports on genes and genomes - 1 Oct 2008
Mizoguchi Hiroshi, Sawano Yoshie, Kato Jun-ichi, Mori Hideo
Abstract excerpt
Escherichia coli has dispensable genome regions and eliminating them may improve cell use by reducing unnecessary metabolic pathways and complex regulatory networks. Although several strains with reduced genomes have already been constructed, there have been no reports of strains constructed with deletions assayed for influence on growth. To retain robust growth and fundamental metabolic pathways, the growth of...
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