Article
Overproduction of threonine by Saccharomyces cerevisiae mutants resistant to hydroxynorvaline.
Applied and environmental microbiology - 1 May 1992
Ramos C, Calderon I L
Abstract excerpt
In this work, we isolated and characterized mutants that overproduce threonine from Saccharomyces cerevisiae. The mutants were selected for resistance to the threonine analog alpha-amino-beta-hydroxynorvalerate (hydroxynorvaline), and, of these, the ones able to excrete threonine to the medium were chosen. The mutant strains produce between 15 and 30 times more threonine than the wild type does, and, to a lesser...
Topics
- Aspartate Kinase
- Drug Resistance, Microbial
- Genes, Dominant
- Genes, Recessive
- Mutation
- Saccharomyces cerevisiae
- Threonine