Article
A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions.
BMC genetics - 2 Jun 2006
Slack Cathy, Somers W Gregory, Sousa-Nunes Rita, Chia William, Overton Paul M
Abstract excerpt
BACKGROUND: The asymmetric segregation of determinants during cell division is a fundamental mechanism for generating cell fate diversity during development. In Drosophila, neural precursors (neuroblasts) divide in a stem cell-like manner generating a larger apical neuroblast and a smaller basal ganglion mother cell. The cell fate determinant Prospero and its adapter protein Miranda are asymmetrically localized...
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