Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of afsA in A-factor biosynthesis as a key enzyme.

The Journal of antibiotics - 1 Oct 1997

Ando N, Matsumori N, Sakuda S, Beppu T, Horinouchi S

Abstract excerpt

The afsA gene of Streptomyces griseus has been postulated to encode a key enzyme for A-factor biosynthesis from primary metabolites commonly present in Streptomyces strains. Escherichia coli cells harboring afsA under the control of the T7 promoter specified distinct A-factor activity in the cult...

Topics

4-Butyrolactone
Bacterial Proteins
Cerulenin
Chromatography, High Pressure Liquid
Escherichia coli
Fatty Acids
Growth Substances
Models, Biological
Mutation
Recombinant Proteins
Streptomyces griseus
Streptomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9402990
DOI: 10.7164/antibiotics.50.847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9402990-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of afsA in A-factor biosynthesis as a key enzyme.PMID 9402990Read ↗

AmfS, an extracellular peptidic morphogen in Streptomyces griseus.Semantic proximity Read ↗

ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones.Semantic proximity Read ↗

Dual transcriptional control of amfTSBA, which regulates the onset of cellular differentiation in Streptomyces griseus.Semantic proximity Read ↗

amfR, an essential gene for aerial mycelium formation, is a member of the AdpA regulon in the A-factor regulatory cascade in Streptomyces griseus.Semantic proximity Read ↗

Control by A-factor of a metalloendopeptidase gene involved in aerial mycelium formation in Streptomyces griseus.Semantic proximity Read ↗

A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp.Semantic proximity Read ↗

Transcriptional switch on of ssgA by A-factor, which is essential for spore septum formation in Streptomyces griseus.Semantic proximity Read ↗

The A-factor-binding protein of Streptomyces griseus negatively controls streptomycin production and sporulation.Semantic proximity Read ↗

Streptomyces griseus 45H, a producer of the extracellular autoregulator protein factor C, is a member of the species Streptomyces albidoflavus.Semantic proximity Read ↗

Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus.Semantic proximity Read ↗

Identification of the SGR6065 gene product as a sesquiterpene cyclase involved in (+)-epicubenol biosynthesis in Streptomyces griseus.Semantic proximity Read ↗

A single target is sufficient to account for the biological effects of the A-factor receptor protein of Streptomyces griseus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.