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Article

Involvement of afsA in A-factor biosynthesis as a key enzyme.

The Journal of antibiotics - 1 Oct 1997

Ando N, Matsumori N, Sakuda S, Beppu T, Horinouchi S

Abstract excerpt

The afsA gene of Streptomyces griseus has been postulated to encode a key enzyme for A-factor biosynthesis from primary metabolites commonly present in Streptomyces strains. Escherichia coli cells harboring afsA under the control of the T7 promoter specified distinct A-factor activity in the culture broth, as determined by induction of streptomycin production and aerial mycelium and spore formation in an...

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PMID: 9402990
DOI: 10.7164/antibiotics.50.847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Involvement of afsA in A-factor biosynthesis as a key enzyme.PMID 9402990Read ↗

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amfR, an essential gene for aerial mycelium formation, is a member of the AdpA regulon in the A-factor regulatory cascade in Streptomyces griseus.Semantic proximity Read ↗

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A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp.Semantic proximity Read ↗

Transcriptional switch on of ssgA by A-factor, which is essential for spore septum formation in Streptomyces griseus.Semantic proximity Read ↗

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