Article
The A-factor-binding protein of Streptomyces griseus negatively controls streptomycin production and sporulation.
Journal of bacteriology - 1 Jun 1990
Miyake K, Kuzuyama T, Horinouchi S, Beppu T
Abstract excerpt
A-factor, 2-(6'-methylheptanoyl)-3R-hydroxymethyl-4-butanolide, is an autoregulator essential for streptomycin production and sporulation in Streptomyces griseus. S. griseus 2247 that requires no A-factor for streptomycin production or sporulation was found to have a defect in the A-factor-binding protein. This observation implied that the A-factor-binding protein in the absence of A-factor repressed the...
Topics
- 4-Butyrolactone
- Carrier Proteins
- Drug Resistance, Microbial
- Growth Substances
- Mutation
- Phenotype
- Pigments, Biological
- Repressor Proteins
- Spores, Bacterial
- Streptomyces griseus
- Streptomycin