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Article

Identification of the SGR6065 gene product as a sesquiterpene cyclase involved in (+)-epicubenol biosynthesis in Streptomyces griseus.

The Journal of antibiotics - 1 Nov 2012

Nakano Chiaki, Tezuka Takeaki, Horinouchi Sueharu, Ohnishi Yasuo

Abstract excerpt

Recent bacterial genome sequencing projects have shown the presence of many putative sesquiterpene cyclase (SC) genes, especially in the Gram-positive, filamentous bacterial genus Streptomyces. We describe here the characterization of a SC gene (SGR6065, named gecA) from Streptomyces griseus. Overexpression of gecA in Streptomyces lividans produced a sesquiterpene, which was isolated and determined to be...

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PMID: 22872183
DOI: 10.1038/ja.2012.68

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