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ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones.

Microbiology (Reading, England) - 1 May 2007

Hsiao Nai-Hua, Söding Johannes, Linke Dirk, Lange Corinna, Hertweck Christian, Wohlleben Wolfgang, Takano Eriko

Abstract excerpt

gamma-Butyrolactones play an important role in the regulation of antibiotic production and differentiation in Streptomyces. However the biosynthetic pathway for these small molecules has not yet been determined, and in vitro synthesis has not been reported. The function of the AfsA family of proteins, originally proposed to catalyse gamma-butyrolactone synthesis, has been in debate. To clarify the function of the...

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PMID: 17464053
DOI: 10.1099/mic.0.2006/004432-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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