Article
Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus.
Journal of bacteriology - 1 Aug 2005
Tomono Ayami, Tsai Yisan, Yamazaki Haruka, Ohnishi Yasuo, Horinouchi Sueharu
Abstract excerpt
A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) triggers streptomycin production by inducing the transcription of strR, encoding the pathway-specific transcriptional activator, through signal transduction in the A-factor regulatory cascade in Streptomyces griseus. AdpA, one of the key transcriptional activators in the cascade, bound two upstream activation sites, approximately at nucleotide...
Topics
- 4-Butyrolactone
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Binding Sites
- DNA Footprinting
- DNA-Binding Proteins
- Deoxyribonuclease I
- Gene Expression Regulation, Bacterial
- Molecular Sequence Data
- Multigene Family
- Mutation
- Promoter Regions, Genetic