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Article

Control by A-factor of a metalloendopeptidase gene involved in aerial mycelium formation in Streptomyces griseus.

Journal of bacteriology - 1 Nov 2002

Kato Jun-ya, Suzuki Ayano, Yamazaki Haruka, Ohnishi Yasuo, Horinouchi Sueharu

Abstract excerpt

In Streptomyces griseus, A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) switches on aerial mycelium formation and secondary metabolite biosynthesis. An A-factor-dependent transcriptional activator, AdpA, activates multiple genes required for morphological development and secondary metabolism in a programmed manner. A region upstream of a zinc-containing metalloendopeptidase gene (sgmA) was found...

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Identifiers

PMID: 12374836
DOI: 10.1128/JB.184.21.6016-6025.2002
PMCID: PMC135398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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