Article
Risk of mother-to-infant transmission of HIV-1 is not reduced in CCR5/delta32ccr5 heterozygotes.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Dec 1997
Edelstein R E, Arcuino L A, Hughes J P, Melvin A J, Mohan K M, King P D, McLellan C L, Murante B L, Kassman B P, Frenkel L M
Abstract excerpt
To determine if the 32-bp deletion of the chemokine receptor CCR5 (delta32ccr5) protects against mother-to-infant transmission of HIV-1, specimens from all uninfected and infected children who were perinatally exposed to HIV-1 and observed since 1988 and whose mothers did not take zidovudine were assessed for delta32ccr5. The CCR5 genotype was determined using polymerase chain reaction (PCR) for 122 subjects, of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.