Article
A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants.
Journal of virology - 1 Dec 1999
Kostrikis L G, Neumann A U, Thomson B, Korber B T, McHardy P, Karanicolas R, Deutsch L, Huang Y, Lew J F, McIntosh K, Pollack H, Borkowsky W, Spiegel H M, Palumbo P, Oleske J, Bardeguez A, Luzuriaga K, Sullivan J, Wolinsky S M, Koup R A, Ho D D, Moore J P
Abstract excerpt
There are natural mutations in the coding and noncoding regions of the human immunodeficiency virus type 1 (HIV-1) CC-chemokine coreceptor 5 (CCR5) and in the related CCR2 protein (the CCR2-64I mutation). Individuals homozygous for the CCR5-Delta32 allele, which prevents CCR5 expression, strongly resist HIV-1 infection. Several genetic polymorphisms have been identified within the CCR5 5' regulatory region, some...
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