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The common Arg 972 polymorphism in insulin receptor substrate‐1 causes apoptosis of human pancreatic islets

14 Nov 2000

Abstract excerpt

Molecular scanning of human IRS-1 gene revealed a common polymorphism causing Gly-->Arg972 change. Diabetic and pre-diabetic carriers of Arg972 IRS-1 are characterized by low fasting levels of insulin and C-peptide. To investigate directly whether the Arg 972 IRS-1 affects human islet cells survival, we took advantage of the unique opportunity to analyze pancreatic islets isolated from three donors heterozygous...

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Share to Endoplasmic Reticulum Stress and Disease
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PMID: 11099486
DOI: 10.1096/fj.00-0414fje

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