Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Point Mutation in the Intracellular Domain of the<i>ret</i>Protooncogene in a Family with Medullary Thyroid Carcinoma<sup>1</sup>

1 Dec 1997

Abstract excerpt

Specific mutations in the ret protooncogene have been found associated with multiple endocrine neoplasia type 2A (MEN 2A) and type 2B (MEN 2B) and familial medullary thyroid carcinoma (FMTC). Mutations in one of five cysteine residues in the extracellular domain have been found in over 95% of families with MEN 2A and 88% of families with FMTC. In MEN 2B patients, a specific mutation at codon 918, substituting a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hedgehog Signaling Pathway Studies
Share to Neuroendocrine Tumor Research Advances
Share to Thyroid Cancer Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9398735
DOI: 10.1210/jcem.82.12.4439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Point Mutation in the Intracellular Domain of the<i>ret</i>Protooncogene in a Family with Medullary Thyroid Carcinoma<sup>1</sup>PMID 9398735Read ↗

Germline Dinucleotide Mutation in Codon 883 of the<i>RET</i>Proto-Oncogene in Multiple Endocrine Neoplasia Type 2B Without Codon 918 MutationSemantic proximity Read ↗

Multiple Endocrine Neoplasia Type 2B with a <i>RET</i> Proto-Oncogene A883F Mutation Displays a More Indolent Form of Medullary Thyroid Carcinoma Compared with a <i>RET</i> M918T MutationSemantic proximity Read ↗

The rare intracellular RET mutation p.S891A in a Chinese Han family with familial medullary thyroid carcinoma.Semantic proximity Read ↗

A Korean family of familial medullary thyroid cancer with Cys618Ser RET germline mutation.Semantic proximity Read ↗

Novel point mutation in exon 10 of the RET proto-oncogene in a family with medullary thyroid carcinoma.Semantic proximity Read ↗

A rare RET mutation in an Indian pedigree with familial medullary thyroid carcinoma.Semantic proximity Read ↗

Two Germline Missense Mutations at Codons 804 and 806 of the <i>RET</i> Proto‐oncogene in the Same Allele in a Patient with Multiple Endocrine Neoplasia Type 2B without Codon 918 MutationSemantic proximity Read ↗

An in-frame complex germline mutation in the juxtamembrane intracellular domain causing RET activation in familial medullary thyroid carcinomaSemantic proximity Read ↗

A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

Molecular Mechanisms of RET Receptor–Mediated Oncogenesis in Multiple Endocrine Neoplasia 2BSemantic proximity Read ↗

Identification of a novel point mutation in the RET gene (Ala883Thr), which is associated with medullary thyroid carcinoma phenotype only in homozygous condition.Semantic proximity Read ↗

A rare <i>RET</i> gene exon 8 mutation is found in two Greek kindreds with familial medullary thyroid carcinoma: implications for screeningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.