Article
The rare intracellular RET mutation p.S891A in a Chinese Han family with familial medullary thyroid carcinoma.
Journal of biosciences - 1 Jun 2014
Qi Xiao-Ping, Zhang Rong-Xin, Cao Jin-Lin, Chen Zhen-Guang, Jin Hang-Yang, Yang Ren-Rong
Abstract excerpt
We report intracellular RET mutation in a Han Chinese pedigree with familial medullary thyroid carcinoma (FMTC). Direct sequencing of RET proto-oncogene identified a missense c.2671T greater than G (p.S891A) mutation in 6 of 14 family members. The single nucleotide polymorphisms c. 135A greater than G (p.A45A), IVS4 + 48A greater than G, c. 1296A greater than G (p.A432A), c. 2071G greater than A (p.G691S), c....
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