A rare <i>RET</i> gene exon 8 mutation is found in two Greek kindreds with familial medullary thyroid carcinoma: implications for screening

Abstract excerpt

OBJECTIVE: Familial medullary thyroid carcinoma (FMTC) is caused by germ-line mutations in the RET proto-oncogene. These mutations concern mainly cysteine residues in exons 10 and 11, whereas noncysteine mutations in exons 13-16 are rare. Mutations in other exons have been reported only in isolated families. In this study we have analysed the RET gene in two FMTC families negative for mutations in the above...

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