Article

Uveal Melanoma Oncogene <i>CYSLTR2</i> Encodes a Constitutively Active GPCR Highly Biased Toward Gq Signaling

2019-06-06

Abstract excerpt

The G protein-coupled receptor (GPCR) cysteinyl-leukotriene receptor 2 (CysLTR2) with a single amino acid mutation at position 3.43 (Leu replaced with Gln at position 129 in transmembrane helix 3) causes uveal melanoma in humans. The ability of CysLTR2-L129Q to cause malignant transformation has been hypothesized to result from constitutive activity. We show that CysLTR2-L129Q is a constitutively active mutant (CA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 416eec9d-d338-5528-8ce9-a4594dd3aad9
DOI: 10.1101/663153

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Uveal Melanoma Oncogene <i>CYSLTR2</i> Encodes a Constitutively Active GPCR Highly Biased Toward Gq SignalingDOI 10.1101/663153Read

Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.Semantic proximity Read

Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma.Semantic proximity Read

Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.Semantic proximity Read

The role of signaling pathways mediated by the GPCRs CysLTR1/2 in melanocyte proliferation and senescence.Semantic proximity Read

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma.Semantic proximity Read

Endothelin signaling promotes melanoma tumorigenesis driven by constitutively active GNAQ.Semantic proximity Read

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.Semantic proximity Read

G‐protein‐coupled receptors and melanomaSemantic proximity Read

Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma.Semantic proximity Read

Functional characterization of uveal melanoma oncogenes.Semantic proximity Read

Going Rogue: Mechanisms, Regulation, and Roles of Mutationally Activated Gα in Human Cancer.Semantic proximity Read

Montelukast as a novel therapeutic approach in metastatic uveal melanoma harboring a CYSLTR2 mutation: a translational case report.Semantic proximity Read