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Article

Constitutively active chemokine CXC receptors.

Advances in pharmacology (San Diego, Calif.) - 1 Jan 2014

Han Xinbing

Abstract excerpt

Chemokines are low-molecular-weight, secreted proteins that act as leukocyte-specific chemoattractants. The chemokine family has more than 40 members. Based on the position of two conserved cysteines in the N-terminal domain, chemokines can be divided into the CXC, C, CC, and CX3C subfamilies. The interaction of chemokines with their receptors mediates signaling pathways that play critical roles in cell...

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Identifiers

PMID: 24931199
DOI: 10.1016/B978-0-12-417197-8.00009-2

Genes

CXCR1
CXCR2
CXCR3
CXCR4

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