Characterization of chimpanzee TCRV gene polymorphism: how old are human TCRV alleles?

doi:10.1007/s002510050336

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Article

Characterization of chimpanzee TCRV gene polymorphism: how old are human TCRV alleles?

Immunogenetics - 1 Jan 1998

Jaeger E E, Bontrop R E, Parham P, Wickings E J, Kadwell M, Lanchbury J S

Abstract excerpt

The functional relevance of the majority of human T-cell receptor A and B variable region gene polymorphisms is controversial. Studies of human and nonhuman primate major histocompatibility complex (MHC) class I and II polymorphisms show that allelic lineages predate human speciation and indicate...

Topics

Alleles
Animals
Base Sequence
DNA
DNA Primers
Evolution, Molecular
Gene Frequency
Gorilla gorilla
Humans
Molecular Sequence Data
Pan troglodytes
Polymorphism, Genetic
Primates
Receptors, Antigen, T-Cell, alpha-beta
Sequence Homology, Nucleic Acid
Species Specificity

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Open in PubMed

Identifiers

PMID: 9396857
DOI: 10.1007/s002510050336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9396857-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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