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Article

Characterization of chimpanzee TCRV gene polymorphism: how old are human TCRV alleles?

Immunogenetics - 1 Jan 1998

Jaeger E E, Bontrop R E, Parham P, Wickings E J, Kadwell M, Lanchbury J S

Abstract excerpt

The functional relevance of the majority of human T-cell receptor A and B variable region gene polymorphisms is controversial. Studies of human and nonhuman primate major histocompatibility complex (MHC) class I and II polymorphisms show that allelic lineages predate human speciation and indicate that selection favors the long-term maintenance of these advantageous mutations. We investigated at the DNA level...

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PMID: 9396857
DOI: 10.1007/s002510050336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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